Compound Proglumide Tablets

Product Introduction

Compound Proglumide Tablets in the prescription of medicine from the medical St. Zhang Zhongjing's "Treatise on" Shaogan Tang, accompanied by western medicine proglumide, the use of modern technology and pharmaceutical technology processing, its unique formula, high technology content, the combination of Chinese and Western medicine, specimens Both governance, significant effect.

Ingredients: prescription form: PROGLUMIDE licorice extract, peony root extract borneol

Prescription analysis: PROGLUMIDE: Department of gastrin receptor antagonists inhibit the secretion of gastrin-induced pepsin, gastric mucosa to protect and promote healing.

White peony: Rougan pain, antispasmodic, town, anti-ulcer effect, white peony root can also stimulate the body immunity, with antibacterial effect, so as to reduce the inflammatory exudation.

Borneol: anti-bacterial, anti-inflammatory, town, can increase the granulation tissue structure and epidermal cell regeneration, promote ulcer healing.

Features

1, Chinese and Western medicine compound preparation, comprehensive effect, tackling the problem, make up for the traditional stomach medicine "single pain, only acid" deficiency.

2, the prescription of traditional Chinese medicine from the medical St. Zhang Zhongjing's "Treatise on" Shaogan Tang, for a century classic name, the exact effect.

3, the product of rapid onset, both acid suppression, pain, anti-inflammatory, repair ulcers, but also long-term stomach, liver protection, gallbladder.

4, sugar-coated tablet form is reasonable, disintegration fast, cover up the bad taste, easy to take, high security.

Mechanism of action

1, proglumide as a antagonist of gastrin, the chemical structure of gastrin (G-17) and cholecystokinin (CCK) two changjitai enterokinase zhongmo terminal chemical structure similar.

Its functional groups amide-based specific properties and gastrin competition on the wall of the gastrin receptor, which can significantly inhibit gastrin-induced gastric acid and pepsin secretion, histamine and vagus nerve stimulation caused by gastric acid secretion Not obvious.

2, can increase the content of gastric mucosal amino sugar, promote glycoprotein synthesis, the protection of the gastric mucosa box to promote healing, can improve the symptoms of peptic ulcer and promote ulcer healing.

3, the application of this product treatment of peptic ulcer and gastritis does not occur gastric acid secretion of the rebound phenomenon, after the termination of treatment can still make gastric acid secretion in the normal level of six months.

4, can relieve gastrointestinal smooth muscle spasm, pain, anti-inflammatory, peony, licorice components containing anti-digestive ulcer substances.

5, the goods have the role of gallbladder; stimulate bile acid, change the bile into stone factors, antagonize CCK dilution bile.

Pharmacokinetics: PROGLUMIDE rapid oral absorption, bioavailability is 60 to 70%, 2-hour plasma concentration reached its peak, the minimum effective blood concentration of 2μg / ml, T1 / 2 was 3.3 hours, mainly distributed In the gastrointestinal tract, liver and kidney, by the kidney, intestinal discharge.

Clinical effect

Compound Proglumide Tablets has been widely used clinically for the treatment of gastric, duodenal ulcers and inflammation.

By the Hunan Provincial People's Hospital, Beijing Friendship Hospital, the 181st Hospital of the People's Liberation Army and other provinces and cities in the fifteen key clinical validation.

In the treatment of stomach, duodenal ulcer and inflammation, the total effective rate was 90.27%, the effect was significant.

1, the total effect: clinical validation of 288 cases, 186 cases of healing, improved 74 cases, 28 cases, the total effect was 90.27%.

2, duodenal ulcer: clinical validation of 184 cases, healing in 119 cases, improved in 46 cases, 19 cases, the rate of 89.67%.

3, gastric ulcer: clinical validation of 69 cases, 44 cases of healing, improved in 19 cases, 6 cases, the efficiency was 91.31%.

4, composite ulcers: clinical validation in 14 cases, 8 cases of healing, improved in 3 cases, 3 cases, the therapeutic rate was 78.57.

5, gastritis: clinical validation in 21 cases, 18 cases of healing, improved in 3 cases, 0 cases, the cure rate was 100%.

Compound Proglumide Tablets

[Drug Name]:

Common name: Compound Proglumide Tablets

 

English name: Compound Proglumide Tablets

Pinyin: Fufang Binggu'an Pian

Ingredients: This product is a compound preparation, its components are: each tablets containing proglumide 100mg, licorice extract 114mg, white peony extract 60mg, borneol 10mg.

[Properties]: This product is sugar-coated tablets, remove the sugar after the brown.

Indications: for gastric and duodenal ulcers, chronic superficial gastritis, duodenal inflammation.

[Specification]: Compound [Usage and dosage] Oral.

Once 3, 4 times a day, before meals or bedtime. 

Two weeks later changed to a 3, 3 day.

Generally 4-6 weeks for a course of treatment.

To consolidate the effect can be extended according to the appropriate period of service period.

[Adverse reactions]

1, occasional dry mouth, constipation, itching, insomnia, abdominal distension, lower limb pain and other adverse reactions.

2, individual reports of transient leukopenia and mild aminotransferase elevation.

3, the goods such as the amount of large, long course of treatment, which licorice extract can make individual patients mildly swollen.

[Taboo] allergic to this product ingredients are disabled.

[Note] medication should avoid tobacco, alcohol and spicy food and trauma.

[Pregnant women and lactating women medication] pregnant women and lactating women with caution [children medication] is not clear [old medication] is not clear [drug interactions] if with other anti-ulcer drugs such as H2 receptor antagonist at the same time, Strengthen the inhibition of gastric acid secretion and accelerate the healing of ulcers.

[Drug overdose] is not yet clear [pharmacology and toxicology] This product of progesterone for gastrin receptor antagonists, which can significantly inhibit gastrin-induced gastric acid and pepsin secretion, and gastric mucosal protection and promotion Healing, can improve the symptoms of peptic ulcer and promote ulcer healing.

This product is still a gallbladder effect.

Licorice extract with Spleen Qi, detoxification effect.

White peony root extract has Pinggan analgesic effect.

Pharmacokinetics is not yet clear.

[Storage] sealed.

[Packing] Medicinal PVC hard film, medicinal PTP aluminum foil blister packaging, 12 tablets / plate × 3plates / box

[Validity] 24 months [Executive Standard] State Food and Drug Administration National Drug Standard WS-10001- (HD-1503) -2004

[Approval number] GYZZ H43021985

[Manufacturer] Hunan Zhongnan Pharmaceutical Co., Ltd.

[Production address]: Longxutang, Shaoxing City, Hunan Province, China

[Postal code]: 422001

[Telephone number]: +86-739-5270030 5270119

[Fax number]: +86-739-5271610